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. Author manuscript; available in PMC: 2022 Feb 4.
Published in final edited form as: Oncogene. 2021 Aug 4;40(39):5788–5798. doi: 10.1038/s41388-021-01982-4

Figure 2. PRC2 directly methylates transcription factors to regulate their functions.

Figure 2.

(A) PRC2 methylates and represses GATA4 activity, whereas PRC2 methylation of STAT3 enhances its transcriptional activity. (B) PRC2 methylates FOXA1 protein to stabilize its protein stability by recruiting a deubiquitinase. PRC2 methylation of RORa, on the other hand, recruits an E3 ligase for proteasomal degradation.