Table 1. EZH2 methylation sites on its histone and non-histone protein substrates.

Shown on each row are the reported substrate, starting aa position, the aa sequence flanking the methylation sites (0 position, highlighted in gray), ending aa position, the functional consequences of the methylation, and the references. AR: a potential substrate, methylation site not mapped.

Substrate	aa	−8	−7	−6	−5	−4	−3	−2	−1	0	1	2	3	4	5	6	aa	Functions	Ref.
Histone H3	19	Q	L	A	T	K	A	A	R	K	S	A	P	A	T	G	33	Transcriptional repression	6, 7
FOXA1	287	A	K	G	G	P	E	S	R	K	D	P	S	G	A	S	351	Protein stabilization	97
RORa	30	P	L	N	Q	E	S	A	R	K	S	E	P	P	A	P	44	Protein degradation	96
PLZF	422	H	R	K	L	H	S	G	M	K	T	Y	G	C	E	L	436	Protein Degradation	98
JARID2	107	R	P	R	L	Q	A	Q	R	K	F	A	Q	S	Q	P	129	Increase PRC2 enzymatic activity	38
STAT3	132	F	D	F	N	Y	K	T	L	K	S	Q	G	D	M	Q	146	Increase transcriptional activity	92
GATA4	291	C	N	A	C	G	L	Y	M	K	L	H	G	V	P	R		Decrease transcriptional activity	94
EloA	746	D	P	R	K	P	A	V	K	K	I	A	P	M	M	A	760	Transcriptional repression	89
Talin1	2446	A	D	Q	D	S	E	A	M	K	R	L	Q	A	A	G	2460	Proteolytic cleavage	101
AR																		Transcriptional activation	90