Table 2:
Summary of association of steps/day cut points to the risk of KR over five years in adults with advanced structural knee OA (Kellgren and Lawrence grade ≥3 in one or both knees) using unadjusted and adjusted Cox regression models (N=516).
| Daily walking cut points | Number of participants | KR n (%) | Unadjusted HR [95% CI] | Adjusted HR [95% CI]† |
|---|---|---|---|---|
| 4,000 steps/day | Below (n=168) | 31 (18) | 1.0 [Reference] | 1.0 [Reference] |
| Equal/Above (n=348) | 57 (16) | 0.83 [0.53, 1.28] | 0.97 [0.58, 1.61] | |
| 5,000 steps/day | Below (n=255) | 47 (18) | 1.0 [Reference] | 1.0 [Reference] |
| Equal/Above (n=261) | 41 (16) | 0.79 [0.52, 1.20] | 0.85 [0.51, 1.39] | |
| 6,000 steps/day | Below (n=322) | 58 (18) | 1.0 [Reference] | 1.0 [Reference] |
| Equal/Above (n=194) | 30 (15) | 0.80 [0.51, 1.24] | 0.83 [0.48, 1.41] | |
| 7,000 steps/day | Below (n=372) | 70 (19) | 1.0 [Reference] | 1.0 [Reference] |
| Equal/Above (n=144) | 18 (13) | 0.62 [0.37, 1.03] | 0.60 [0.34, 1.06] | |
| 8,000 steps/day | Below (n=421) | 74 (18) | 1.0 [Reference] | 1.0 [Reference] |
| Equal/Above (n=95) | 14 (15) | 0.79 [0.45, 1.40] | 0.74 [0.40, 1.39] | |
| 9,000 steps/day | Below (n=459) | 80 (17) | 1.0 [Reference] | 1.0 [Reference] |
| Equal/Above (n=57) | 8 (14) | 0.47 [0.37, 1.59] | 0.70 [0.33, 1.51] | |
| 10,000 steps/day | Below (n=478) | 85 (18) | 1.0 [Reference] | 1.0 [Reference] |
| Equal/Above (n=38) | 3 (8) | 0.42 [0.13, 1.32] | 0.38 [0.12, 1.23] |
HR=hazard ratio CI=confidence interval
†
Adjusted for age, BMI, sex, education, race, index knee pain defined using most painful knee on visual analog scale, comorbidities, and previous knee injuries/surgeries