Fig. 2.

The cytokine profile of pEV is associated with allergies. (A) Illustration of the observed per-sample abundances of 3 specific measured cytokines: IL-1A (top, the least different among the cohorts), IL-27 (middle, highest gross decrease in patients with allergies), and TNF (bottom, highest gross increase in patients with allergies). Horizontal grey lines indicate cohort averages. (B) Dimensional reduction of the full data set via principal component analysis (PCA). Approximately half of the observed variance can be explained by the first 2 principal components. The control and the allergy cohorts occupy distinct but partially overlapping regions in the plot, arguing for an allergy-specific pattern in the measured cytokine profiles. (C) Heat map and hierarchical clustering of the full data set. While some subgroups within both cohorts cluster together, there is no high-level separation between allergy and control samples