FigS2.

Diabetic stress mainly affects the β-cells transcriptome and, to a low extent, that of α-, δ- and PP-cells. a–d, Volcano plots showing numbers of significantly differentially expressed genes, comparing Sham versus WT in (a) β-cells, (b) α-cells, (c) δ-cells and (d) PP-cells with a threshold at an absolute estimated logFC > 0.15, B > 150, adjusted p < 0.01. e, UMAP plot showing WT- and Sham-derived α-cells (3279 cells in total) based on the expression of hormone glucagon (Gcg) and depicting co-expression of Mafb and Ppy. f, Bar plot showing the log(FC) differences between WT- and Sham-derived α-cells for a selection of genes. g, Selected Gene Ontology (GO) terms from enrichment analysis of significantly up- and downregulated genes in α-cells of Sham compared to WT at absolute estimated log(FC) > 0.15 and B > 20.