Table 1.

Endogenous Dectin-1 ligands

	Initial identification	Downstream effects	Glycosylation dependent?	Binding blocked by β- glucan?	Species	Citations
Unknown protein expressed on the surface of T cells	Extracellular domain of Dectin-1 bound to surface of T cell lines	T cell proliferation	No	No	Mouse, human	[72,94]
Vimentin	Affinity purification MS using anti-zymosan Ab and human atherosclerotic plaque tissue	ROS production	Unk.	Unk.	Human	[73,74]
IgG antibody
Galactosylated IgG1 ICs	Dectin-1 dependent function of IgG immune complexes in vivo	With FcγRIIb, inhibited C5a chemotaxis	Yes	Unk.	Mouse	[25]
			Yes	No	Mouse	[77]
Core fucose of IgG	Surface plasmon resonance			(IgG)
IgA antibody	Dectin-1 dependent reverse transcytosis of SIgA (in vitro and in vivo)	SIgA transcytosis, with Siglec5	Yes	Yes	Mouse, human	[1]
MUC2	Dectin-1 dependent binding of MUC2 by DCs	With galectin-3 and FcγRIIb, activates β-catenin and tolerogenic immune response	Yes	Unk.	Mouse, human	[26]
Galectin-9	Affinity-purification MS using anti-Dectin1 Ab and mouse pancreatic cancer tissue	p-Syk; tolerogenic immune response; pro-tumorigenic (PDA)	No	Yes	Mouse, human	[15,30]
Annexins	Surface plasmon resonance	p-Syk (Tyr348/352); NOX-2; tolerogenic immune response	Unk.	No	Mouse, human	[75]
N-glycosylated proteins on cancer cells	Dectin-1 dependent, N-glycan dependent anti-tumor activity (B16 melanoma)	IRF5 activation; promotes anti-tumor activity (B16 melanoma)	Yes	Unk.	Mouse, human	[29,76]

Unk.: Unknown