. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Trends Immunol. 2021 Sep 4;42(10):891–903. doi: 10.1016/j.it.2021.08.005

Table 2.

Studies of Dectin-1 function in animal models of CNS pathology

CNS disease model	Reported Effect	Approach	Species	Citation
Stroke	Detrimental	Laminarin (i.p.); Piceatannol (Syk inhibitor)	Mouse B6	[95] [96]
Spinal cord injury	Detrimental	Zymosan, d-zymosan; Clec7a^−/− mice	Mouse B6	[36]
Optic nerve injury	Beneficial	Zymosan, curdlan (i.o.); Clec7a^−/−; Card9^−/− mice	Mouse B6	[45,46]
EAE	Beneficial [TLR2 focus]	Zymosan (i.p.)	Mouse SJL, B6	[47]
	Detrimental [TLR2 focus]	Zymosan (i.c.v.)	Mouse SJL	[48]
	Beneficial [Dectin-1 focus]	Clec7a^−/−; Card9^−/− mice; d-zymosan (i.v.)	Mouse B6	[15]
CNS infection: Candida albicans	Beneficial	Clec7a^−/−; Card9^−/− mice	Mouse B6	[62,63]
CNS infection: Neospora caninum	Detrimental	Clec7a^−/− mice	Mouse B6	[63]