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. Author manuscript; available in PMC: 2022 Feb 20.
Published in final edited form as: Nat Immunol. 2021 Aug 20;22(10):1306–1315. doi: 10.1038/s41590-021-01021-0

Fig. 3. T cell responses following mRNA-1273 immunization.

Fig. 3.

Twenty-four rhesus macaques were immunized according to Extended Data Fig. 1, and compared to eight age-matched controls. Intracellular staining was performed on PBMCs at week 7 to assess T cell responses to SARS-CoV-2 S protein peptide pools, S1 and S2. Responses to S1 and S2 individual peptide pools were summed. (A) Th1 responses (IFNg, IL-2, or TNF), (B) Th2 responses (IL-4 or IL-13), (C) Tfh CD40L upregulation (peripheral follicular helper T cells (Tfh) were gated on central memory CXCR5+PD-1+ICOS+ CD4 T cells), (D) Tfh IL-21, (E) CD8 T cells. Data represents one independent experiment. Boxes and horizontal bars denote IQR and medians, respectively; whisker end points are equal to the maximum and minimum values. Circles represent individual NHP. Dotted lines are set to 0%.