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. 2021 Sep 29;14:4987–5000. doi: 10.2147/JIR.S329234

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© 2021 Hong et al.

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MMP-7 directly induces shedding of syndecan-2 in colon tissues. (A) Seven-week-old C57BL/6 mice were administrated with 3% DSS for 4 days, and colon sections of each group were H&E stained or immunostained with the indicated antibodies. Scale bars: 50 μM. (B) Colon tissues dissected from mice were ex vivo cultured and treated with MMP-7 (320 nM) for 2 hr in the absence (left panel, n=5) or presence (right panel, n=3) of MMP-7 inhibitor (GM6001). The cultured media was analyzed by slot blotting with anti-syndecan-2 antibody. Box-whisker plot represented the level of shed syndecan-2 using shed syndecan-2 level of vehicle as a control (n=5). *p < 0.05, **p < 0.01.