Table 2.

Summary of the directions of changes in expression levels of HPA axis regulating and neurostructural marker proteins in response to single acute (foot-shock) or prolonged (RSI, RSII) stress in the WT mouse brain.

Proteins	PTSD mouse model (t-tests)						WT mice of Fkbp5 KO mouse model (Bonferroni post-tests)
	Hippocampus			Cerebellum			Hippocampus		PFC		Cerebellum
	d2	d28	d60	d2	d28	d60	RSI	RSII	RSI	RSII	RSI	RSII
GR	–	–	–	↓ (t) FDR: ns	↓	↓	↔	↓	↔	↓	↔	↔
FKBP51	–	–	–	↔	↔	↓	↔	↓	↔	↓	↔	↓
FKBP52	–	–	–	↓	↔	↔	↔	↓	↔	↓	↔	↓ FDR S: ns
MR	–	–	–	–	–	–	–	–	–	–	↔	↔
HSP90	–	–	–	↔	↔	↔	–	–	–	–	–	–
NF–H	↓	↔	↓ (t)	↔	↔	↑	–	–	–	–	↓	↔
Synaptophysin	↓ (t)	↔	↓	↓	↔	↔	↔	↑	↔	↑	↔	↔
HOMER1 b/c	↔	↔	↓	↓	↓ (t) FDR: ns	↔	–	–	–	–	↔	↔
MAP-2	↔	↔	↔	↔	↔	↔	↔	↔	↔	↔	↔	↔
GFAP	↔	↔	↔	↓	↔	↑	↔	↑	↔	↔	↔	↔

Data on cerebellar expression levels as well as on hippocampal and prefrontal cortical FKBP52 expression were taken from Figss. 1–3 (t-tests and Bonferroni post-tests from ANOVAs) and the other data from three of our previous publications (Herrmann et al., 2012; Schmidt et al., 2015; Touma et al., 2011). Symbols: ↑, increase in relation to unstressed controls; ↓, decrease in relation to unstressed controls; ↔ no statistically significant change in relation to unstressed controls; (t), statistical trend for a significant change; FDR, Benjamini-Hochberg false discovery rate (FDR) correction; S FDR, FDR-correction of main effect of Stressor (ANOVA). Note that FDR and FDR S are only listed in case FDR-correction has diminished the significance level of the respective result and that both FDR and FDR S have only been calculated for results gained in cerebellar samples. Abbreviations: PTSD, posttraumatic stress disorder; Fkbp5, gene encoding for FK 506 binding protein 51; KO, knockout; WT, wildtype; d2, d28 and d60: 2, 28 or 60 days after exposure to a single foot-shock or mock-treatment; abbreviations of proteins are explained in the main text. RSI and RSII are explained in detail in the methods chapter and are illustrated in Fig. 2A.