Table 1.
Therapeutic application of mitochondrial dynamics and mitophagy.
| Injury factors | Key protein | Representative interventions | Mechanisms | Effects to cardiotoxicity |
|---|---|---|---|---|
| Hypoxia | FUNDC1 | Hypoxia preconditioning | Mitophagy | Protection |
| Hypoxia | DRP1 | Schaftoside | Fission | Protection |
| OS | PINK1 | Zine, Melatonin | Mitophagy | Protection |
| OS | BNIP3 | Acute exercise | Mitophagy | Protection |
| OS | DRP1 | Melatonin | Fission | Protection |
| Hyperglycemia | DRP1 | Metformin | Fission | Protection |
| Hyperglycemia | MFN1 | Metformin | Fission | Protection |
| Anthracyclines poisoning | BNIP3 | Acute exercise | Mitophagy | Protection |
| Organophosphate poisoning | Parkin | Salidroside | Mitophagy | Protection |
| Nicotine poisoning | OPA1 | MYLS22 | Fusion | Protection |