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. 2021 Sep 20;8:698337. doi: 10.3389/fmolb.2021.698337

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Copyright © 2021 Letertre, Giraudeau and de Tullio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Typical fast 2D NMR pulse sequences for high-throughput metabolomics and their corresponding spectrum obtained on a model mixture of metabolites (A,D) Ultrafast ¹H–¹H correlation spectroscopy (UF COS)Y (B,E) Z-filter ¹H–¹H total correlation spectroscopy (ZF-TOCSY) with 50% of non-uniform sampling in the indirect dimension (C,F) ¹H–¹³C heteronuclear single-quantum correlation (HSQC) with 25% of non-uniform sampling in the indirect dimension. Pulse sequences offer complementary performances in terms of speed, resolution and sensitivity. Adapted with permission from (Martineau et al., 2020).