Table 3.

The proportion of genes associated with neuronal and synaptic functions.

	Neuronal genes (observed)	Corresponding genes	Expected	Observed/expected	P -value
Responder
Changed methylation sites	300 (16.8%)	1,789	277.5	1.081	0.008
DEGs around changed methylation sites	30 (35.7%)	84	13	2.302	2.96.E-06
Gene body (same direction) and Promoter (opposite direction)	19 (40.4%)	47	7.3	2.606	2.53.E-05
Non-responder
Changed methylation sites	190 (16.6%)	1,145	177.6	1.07	0.019
DEGs around changed methylation sites	1 (6.7%)	15	2.3	0.43	0.22
Gene body (same direction) and Promoter (opposite direction)	0 (0.0%)	5	0.8	0	0.43

P-values were calculated by hypergeometric distribution test.