TABLE 4.
The KEGG pathway analysis results of differently expressed up-regulated genes and differently expressed down-regulated genes.
| Oncogenes | Pathway ID | Amount of genes | Names | Pathway description | P value |
| Up-regulated genes | 00500 | 6 | AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, PGM2L1 | Starch and sucrose metabolism | 2.34e-4 |
| 04110 | 11 | BUB1B, CCNB1, CDC20, CDK1, CDKN2A, MAD2L1, MCM2, ORC6, PTTG1, SFN, TTK | Cell cycle | 1.06e-5 | |
| 04115 | 7 | CCNB1, CDK1, CDKN2A, IGFBP3, RRM2, SFN, STEAP3 | p53 signaling pathway | 9.95e-4 | |
| 04512 | 10 | COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL11A1, COMP, HMMR, SPP1, THBS2 | Extracellular matrix receptor interaction | 2.01e-5 | |
| 04974 | 10 | ACE2, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL11A1, DPP4, KCNN4, KCNK5 | Digestion and absorption of protein | 2.78e-6 | |
| Down-regulated genes | 04062 | 16 | ARRB1, CCL2, CCL4, CCL14, CCL21, CCL23, CXCL3, CXCL12, CXCR2, CX3CL1, ELMO1, FGR, GNG11, PLCB4, PPBP, PREX1 | Chemokine signaling transduction pathway | 1.37e-5 |
| 04514 | 12 | CADM1, CDH5, CD274, CLDN5, CLDN18, CLDN22, ESAM, ICAM1, ICAM2, PECAM1, PTPRM, SELP | Cell adhesion molecule | 1.46e-3 | |
| 04668 | 13 | CCL2, CXCL3, CX3CL1, EDN1, FOS, ICAM1, IL1B, IL18R1, IL6, JUNB, MAP3K8, PTGS2, TNFAIP3 | TNF signaling pathway | 1.69e-6 | |
| 05143 | 7 | ICAM1, IL1B, IL6, HBA1, HBA2, HBB, PLCB4 | African trypanosomiasis | 1.54e-4 | |
| 05144 | 14 | CCL2, CD36, CSF3, GYPC, HBA1, HBA2, HBB, ICAM1, IL1B, IL6, KLRB1, PECAM1, SELE, SELP | Malaria | 1.01e-11 |