FIGURE 2.

Changes in lung microbiome composition and bacterial load during study. a) (Shannon-) α-diversity showed no significant differences by treatment group (p=0.858, Wilcoxon rank-sum test) using pooled samples across visits between treatment groups. b) Changes in relative abundance of Proteobacteria (including Haemophilus) during the study. No significant differences in a linear mixed-effects (LME) model (using the patient as a random effect) were observed between danirixin (n=12) and placebo (n=5) groups (p=0.174). c) No significant differences in bacterial load as measured via 16S quantitative PCR between danirixin and placebo groups were observed (p=0.8551, LME). d,e) Overall microbiome composition was similar between danirixin and placebo groups at the d) phylum and e) genus levels.