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. 2021 Sep 20;9:734720. doi: 10.3389/fcell.2021.734720

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Copyright © 2021 Claridge, Lozano, Poh and Greening.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Challenges and translational considerations of development of EV-based therapeutics. Developing rational targeting or therapeutic strategies for these different stages will advance the application of EV-based therapeutics.