Figure 2.

Segregation of patient groups by the composition of lipidomes. A: PCA plot for full lipidomes of liver biopsies of 365 patients, whose disease group is indicated by color (coding scheme is in the inset); (B) PCA plot of lipidomes from which glycerolipids and CE were omitted. C: Length and unsaturation of fatty acid moieties in TG and DG species. Circle size and color reflect lipid abundances. D: Similarity network of biclusters. Node size is proportional to the number of patients in the bicluster. Highlighted are four network components (annotated) comprising the largest number of connected biclusters attributed to steatotic (in red and amber for NASH and NAFL) or nonsteatotic patients (in blue and green for NC and HO).