FIGURE 8.

Histopathological examination of skin mice of control groups during 1st stage (B,C) and 2nd stage of treatment (D,E). G1 is negative control comprised neither burned nor infected mice (A). G2 is positive control; mice skin were burnt and get infected with P. aeruginosa P8 without receiving any treatment (B,D). G3 is positive control; mice skin were burnt, and get infected with P. aeruginosa P8 and received treatment with placebo gel only (C,E). Magnification power (200×). (B) Loss of epidermis (blue arrow), distortion in the dermis layer with irregular distribution of collagen (circle). (C) Epidermis loss (thin arrow), underlying massive infiltration (thick arrow), and edema space in the dermis layer (blue arrow). (D) Irregular epidermis layer, infiltration with inflammatory cells (black arrow) with distortion in the glands within the dermis layer (circle), and large lytic area (blue arrow). (E) Separation of epidermis from the dermis layer with underlying inflammatory cells and irregular distribution of collagen in dermis layer underlying edema space (blue arrow).