Table 4.

Adaptive transfer of ex-expanded lymphocytes.

Subsets	Dosages	Species of recipients	Methods	Effects	References
Tregs	1.0 × 105 cells	Mouse	Before IR	Wild-type Tregs protected mice from IRI.	Dong et al., 2019
				CD73-deficient or A2AR-deficient Tregs failed to protected mice from IRI.
				Pharmacologic stimulation of A2AR on Tregs augmented the protective functions.
Tregs	2.0 × 106 cells	Mouse	24 h before cisplatin administration	Adaptive transfer of wild-type Tregs resulted in less severe cisplatin-induced AKI than that of TLR9-deficient Tregs.	Kinsey et al., 2010
				TLR9 promoted Treg recruitment.
Tregs	50 × 103 cells	Mouse	24 h before IR	Tregs from IL-233-treated mice played better protective roles in IRI at lower doses (50 × 103).	Mu et al., 2020
	100 × 103 cells			Tregs at higher doses (100 × 103) had no protective roles.
Tregs	2.0 × 106 cells	Mouse	24 h after IR	Rapamycin-treated Tregs enhanced beneficial effects on reducing IRI on the early (3 d) and later (14 d) repair stages.	Krabbendam et al., 2018
Tregs	1.2 × 106 cells	Mouse	24 h after IR	Tregs promoted kidney repair after IRI.	Liu et al., 2018
DNT cells	1.0–1.5 × 106 cells	Mouse	24 h before cisplatin administration	DNT cells attenuated cisplatin-induced AKI.	Alexander et al., 2020
DNT cells	2.5 × 106 cells	Mouse	24 h before IR	DNT cells protected mice from AKI in a IL-10-dependent manner.	Diao et al., 2019
ILC2s	1.0 × 106 cells	Mouse	24 h before IR	IL-33-treated ILC2s prevented renal injury in an Areg-dependent manner.	Wang Y. M. et al., 2017
				Human-derived ILC2s ameliorated renal IRI in mice.
ILC2s	5.0 × 105 cells	Mouse	24 h before IR	IL-233-treated ILC2s protected mice from IRI	Mu et al., 2020