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. 2021 Sep 20;15:727336. doi: 10.3389/fncel.2021.727336

Table 1.

Selected publications on Spike Timing-Dependent Plasticity.

Reference Synapses Induction protocol Plasticity observed [Ca2+]e
Debanne et al. (1994) CA3-CA1 50–100 pairings @ 0.3 Hz + Postsynaptic burst LTD (Δt < 0 ms) 2.8 mM
Bi and Poo (1998) Hippocampal 60 pairings @ 1 Hz + Postsynaptic depolarization LTP (Δt > 0 ms) and LTD (Δt < 0 ms) 3 mM
neurons
Markram et al. (1997) L5-L5 10 pairings @ 20 Hz (2:2 or 5:5 or 10:10) LTP (Δt > 0 ms) 2 mM
Sjöström et al. (2001) L5-L5 15 pairings @ 40 Hz (1:5) LTP (Δt > 0 ms) 2.5 mM
Froemke et al. (2006) L2/3 60–100 pairings @ 0.2 Hz (1:1) LTP (Δt > 0 ms) and LTD (Δt < 0 ms 2.5 mM
Froemke et al. (2006) L2/3 30–40 pairings @ 0.2 Hz (5:5) No Plasticity, LTD or LTP depending on burst frequency 2.5 mM
Wittenberg and Wang (2006) CA3-CA1 70–100 pairings @ 0.1–0.5 Hz (1 :1) LTD only (Δt > 0 ms and Δt < 0 ms) 2 mM
Wittenberg and Wang (2006) CA3-CA1 100 pairings @ 5 Hz (1:2) LTD (Δt < 0 ms) and LTP (Δt > 0 ms) 2 mM
Nishiyama et al. (2000) CA3-CA1 Train of stimuli at 5 Hz + postsynaptic Spike LTP (Δt > 0 ms) and LTD (Δt < 0 ms)* 2–2.6 mM
Campanac and Debanne (2008) CA3-CA1 100 pairings @ 0.3 Hz for LTP LTD (Δt < 0 ms) and LTP (Δt > 0 ms) 3 mM
150 pairings @ 0.3 Hz for LTD (1:1)
Pawlak and Kerr (2008) Corticostriatal 60 pairings @ 0.1 Hz (1:1) LTD (Δt < 0 ms) and LTP (Δt > 0 ms) 2.5 mM
pathway
Mishra et al. (2016) CA3-CA3 300 pairings @ 1 Hz (1:1) LTP only (Δt > 0 ms and Δt < 0 ms) 2 mM
Inglebert et al. (2020) CA3-CA1 100 pairings @ 0.3 Hz for LTP No Plasticity or LTD only 1.3–1.8 mM
150 pairing @ 0.3 Hz for LTD (1:1)

This table summarizes the plasticity observed in several studies as a function of extracellular calcium concentration. The brain region studied and the induction protocol used are also indicated. The number of repetitions, the pairing frequency and number of pre/post stimulation are specified. For example, 5:5 indicates five presynaptic and five postsynaptic stimulations. *A second LTD window is visible around Δt = 20 ms. STDP, Spike Timing-Dependent Plasticity.