Table 1.
Selected publications on Spike Timing-Dependent Plasticity.
| Reference | Synapses | Induction protocol | Plasticity observed | [Ca2+]e |
|---|---|---|---|---|
| Debanne et al. (1994) | CA3-CA1 | 50–100 pairings @ 0.3 Hz + Postsynaptic burst | LTD (Δt < 0 ms) | 2.8 mM |
| Bi and Poo (1998) | Hippocampal | 60 pairings @ 1 Hz + Postsynaptic depolarization | LTP (Δt > 0 ms) and LTD (Δt < 0 ms) | 3 mM |
| neurons | ||||
| Markram et al. (1997) | L5-L5 | 10 pairings @ 20 Hz (2:2 or 5:5 or 10:10) | LTP (Δt > 0 ms) | 2 mM |
| Sjöström et al. (2001) | L5-L5 | 15 pairings @ 40 Hz (1:5) | LTP (Δt > 0 ms) | 2.5 mM |
| Froemke et al. (2006) | L2/3 | 60–100 pairings @ 0.2 Hz (1:1) | LTP (Δt > 0 ms) and LTD (Δt < 0 ms | 2.5 mM |
| Froemke et al. (2006) | L2/3 | 30–40 pairings @ 0.2 Hz (5:5) | No Plasticity, LTD or LTP depending on burst frequency | 2.5 mM |
| Wittenberg and Wang (2006) | CA3-CA1 | 70–100 pairings @ 0.1–0.5 Hz (1 :1) | LTD only (Δt > 0 ms and Δt < 0 ms) | 2 mM |
| Wittenberg and Wang (2006) | CA3-CA1 | 100 pairings @ 5 Hz (1:2) | LTD (Δt < 0 ms) and LTP (Δt > 0 ms) | 2 mM |
| Nishiyama et al. (2000) | CA3-CA1 | Train of stimuli at 5 Hz + postsynaptic Spike | LTP (Δt > 0 ms) and LTD (Δt < 0 ms)* | 2–2.6 mM |
| Campanac and Debanne (2008) | CA3-CA1 | 100 pairings @ 0.3 Hz for LTP | LTD (Δt < 0 ms) and LTP (Δt > 0 ms) | 3 mM |
| 150 pairings @ 0.3 Hz for LTD (1:1) | ||||
| Pawlak and Kerr (2008) | Corticostriatal | 60 pairings @ 0.1 Hz (1:1) | LTD (Δt < 0 ms) and LTP (Δt > 0 ms) | 2.5 mM |
| pathway | ||||
| Mishra et al. (2016) | CA3-CA3 | 300 pairings @ 1 Hz (1:1) | LTP only (Δt > 0 ms and Δt < 0 ms) | 2 mM |
| Inglebert et al. (2020) | CA3-CA1 | 100 pairings @ 0.3 Hz for LTP | No Plasticity or LTD only | 1.3–1.8 mM |
| 150 pairing @ 0.3 Hz for LTD (1:1) |
This table summarizes the plasticity observed in several studies as a function of extracellular calcium concentration. The brain region studied and the induction protocol used are also indicated. The number of repetitions, the pairing frequency and number of pre/post stimulation are specified. For example, 5:5 indicates five presynaptic and five postsynaptic stimulations. *A second LTD window is visible around Δt = 20 ms. STDP, Spike Timing-Dependent Plasticity.