FIGURE 4.

AMO-loaded exosomes suppressed tumor growth in vivo. (A) HCT116 tumor-bearing mice received 3 intratumoral injections of exosome drugs on days 0, 3, and 7. In vivo imaging of the mice was performed once a week to observe the change of fluorescence value. (B) Tumor changes in mice were measured with a vernier caliper. (C) The level of miR-221 in the dissected mouse tumor tissues was detected by quantitative PCR. (D) The mRNA levels of downstream target genes of miR-221 in the dissected mouse tumor tissues were detected by quantitative PCR. *p < 0.05, **p < 0.01.