Table 3.

The adverse events and laboratory findings in patients with severe COVID-19

Adverse event	Counts	CRP			NLR			D-dimer
		Median (IQR, mg/L)	U value	P value	Median (IQR)	U value	P value	Median (IQR, μg/mL)	U value	P value
Clinical outcomes			4.026	<0.05	NLR	4.097	<0.05	D-dimer	4.279	<0.05
Death	61 (32.1%)	97.7 (63.6–179.1)			13.5 (7.3–20.8)			7.979 (0.495–25.253)
Alive	129 (67.9%)	61.4 (26.7–101.5)			6.7 (3.7–12.4)			0.604 (0.169–2.877)
Mechanical ventilation			4.302	<0.05		3.897	<0.05		4.904	<0.05
Yes	70 (36.8%)	92.2 (64.4–168.2)			12.9 (7.0–19.8)			5.580 (0.512–22.018)
No	120 (63.2%)	59.9 (22.7–99.8)			6.6 (3.6–11.5)			0.436 (0.151–2.618)
Intensive care unit admission			2.955	<0.05		2.925	<0.05		2.688	<0.05
Yes	46 (24.2%)	97.7 (64.4–168.2)			14.8 (6.2–21.8)			2.357 (0.498–15.210)
No	144 (75.8%)	62.9 (30.2–121.9)			7.3 (4.0–13.0)			0.613 (0.210–4.354)
Multiple organ dysfunction syndrome			4.563	<0.05		4.774	<0.05		5.160	<0.05
Yes	98 (51.6%)	85.5 (59.9–146)			12.3 (6.2–18.5)			2.493 (0.495–13.105)
No	92 (48.4%)	53.3 (16.9–92.5)			5.6 (2.9–11.0)			0.347 (0.144–1.027)
Acute myocardial injury			3.621	<0.05		3.497	<0.05		4.946	<0.05
Yes	77 (44.8%)	92.2 (59.5–145.8)			11.7 (5.9–18.6)			4.596 (0.615–14.730)
No	95 (55.2%)	60.8 (22.7–99.8)			6.7 (3.1–11.9)			0.392 (0.150–1.611)
Acute kidney injury			2.892	<0.05		2.506	<0.05		2.709	<0.05
Yes	43 (23.5%)	92.2 (58.4–195.5)			13.1 (5.8–23.4)			4.651 (0.495–15.858)
No	140 (76.5%)	64.7 (29.7–108.8)			7.6 (3.8–13.4)			0.613 (0.232–3.476)
Respiratory failure			3.052	<0.05		2.272	<0.05		4.640	<0.05
Yes	170 (89.5%)	76.0 (40.8–135.2)			9.7 (4.4–15.4)			4.651 (0.495–19.155)
No	20 (10.5%)	17.1 (6.7–68.5)			4.9 (3.0–8.9)			0.509 (0.151–2.461)

Continuous variables were described as median with IQR and analysed by Mann-Whitney test. P values indicate differences of laboratory indicators in severe COVID-19 patients with and without adverse events. P<0.05 was considered statistically significant.

CRP, C reactive protein; NLR, neutrophil-to-lymphocyte ratio.