Table 3.

Adverse Events of Any Cause.

Event	Cohort A (N = 8)		Cohort B (N = 9)
	Any Grade	Grade 3 or 4	Any Grade	Grade 3 or 4
Any event	8 (100)	2 (25)	9 (100)	3 (33.3)
Anemia	6 (75)	2 (25)	7 (77.8)	1 (11.1)
Constipation	6 (75)	0	0	0
Fatigue	4 (50)	0	1 (11.1)	0
Decreased appetite	3 (37.5)	0	2 (22.2)	0
Skin reactions	3 (37.5)	0	2 (22.2)	0
Peripheral edema	3 (37.5)	0	1 (11.1)	0
Mucosal inflammation	3 (37.5)	0	1 (11.1)	0
Hyperthyroidism	2 (25)	0	1 (11.1)	0
Diabetes	2 (25)	0	0	0
Hepatitis	2 (25)	0	2 (22.2)	1 (11.1)
Dizziness	2 (25)	0	0	0
Neutrophil count decreased	1 (12.5)	0	3 (33.3)	1 (11.1)
Pneumonitis	1 (12.5)	0	0	0
Vomiting	1 (12.5)	0	0	0
Hypothyroidism	1 (12.5)	0	0	0
Nephritis	1 (12.5)	0	0	0