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. 2021 Sep 20;12:744561. doi: 10.3389/fneur.2021.744561

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Copyright © 2021 Watanabe, Watanabe, Takao, Hong, Liu, Suga, Tu, Sakamoto, Umezaki, Yoshikawa, Takenoshita, Uezato, Motomura, Kurabayashi, Abiko and Toyofuku.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The oral DRS scores in the patients having predominantly unilateral OC with and without NVC. (A) The overall subjective severity of OC symptoms: The patients without NVC presented significantly higher VAS scores that indicate overall subjective severity of OC symptoms according to Student's t-test. (B) The Oral DRS scores: The patients without NVC showed significantly higher scores in the parameters of movement, work, and social activities than patients with NVC. Mann–Whitney U-test was used for each parameter. (C) The total scores of corresponding categories in the SSS and FIS: The patients without NVC showed significantly higher averages of the total scores and the number of corresponding symptoms in both the SSS and FIS than the patients with NVC based on Student's t-test. (D) Total number of corresponding categories in the SSS and FIS: The patients without NVC showed significantly higher number of the total number of corresponding symptoms in both the SSS and FIS than the patients with NVC according to Mann–Whitney U-test. For the box-and-whisker plot in panels (A,C,D) the line in the middle indicates the median; the top and bottom lines show the first and third quartiles. The cross marks show the mean values, and the whiskers extend to 1.5 times the height of the box or, if no case/row has a value in that range, to the minimum or maximum values. The points are outliers. VAS, Visual Analog Scale; Oral DRS, Oral Dysesthesia Rating Scale; OC, oral cenesthopathy; NVC, neurovascular contact; SSS, symptom severity scale; FIS, functional impairment scale.