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. 2021 Sep 21;12:100139. doi: 10.1016/j.mtbio.2021.100139

Fig. 1.

Fig. 1

Paeoniflorin modulates the phenotype and function of macrophages. (A) The chemical structure of paeoniflorin (PF). (B) The CD86+ and F4/80+ population (%) in LPS- and IFN-γ-stimulated BMDMs following treatment of DMSO and PF (10, 25 and 50 μM) (n = 3; ∗p < 0.05 and NS = no significance). (C) The CD206+ and F4/80+ population (%) in LPS- and IFN-γ-stimulated BMDMs following treatment of DMSO and PF (10, 25 and 50 μM) (n = 3; ∗p < 0.05 and NS = no significance). (D) The ratio of M2 cells (CD206+ and F4/80+) versus M1 cells (CD86+ and F4/80+) (n = 3; ∗p < 0.05 and NS = no significance). (E) The mRNA expression of cytokines in LPS- and IFN-γ-stimulated BMDMs following treatment of DMSO and PF (50 μM) (n = 3; ∗p < 0.05 and NS = no significance). (F) The release of cytokines in LPS- and IFN-γ-stimulated BMDMs following treatment of DMSO and PF (50 μM) (n = 3; ∗p < 0.05 and NS = no significance). (G) The activity of STAT signaling pathway in LPS- and IFN-γ-stimulated BMDMs following treatment of DMSO and PF (50 μM). The relative expression of the proteins of interest was quantified in Fig. S3.