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. 2021 Sep 21;12:100139. doi: 10.1016/j.mtbio.2021.100139

Fig. 4.

Fig. 4

HA-PF promotes diabetic wound healing via modulation of macrophages. (A) The population (%) of iNOS+ F4/80+ and Arg-1+ F4/80+ macrophages within the wound was determined using immunofluorescent assay (n = 4; ∗p < 0.05 and NS = no significance). (B) The mRNA expression of cytokines in the wound following treatment of blank HA, INTRASITE gel, and HA-PF (containing 500 μM of PF) (n = 4; ∗p < 0.05 and NS = no significance). (C) The release of cytokines in the wound following different treatments (n = 4; ∗p < 0.05). (D) The mRNA expression of CD31, VEGF, α-SMA and type I collagen in the wound following different treatments (n = 4; ∗p < 0.05 and NS = no significance). (E) The expression of CD31 in the wound was determined using immunofluorescent assay (n = 4; ∗p < 0.05 and NS = no significance). (F) The expression of α-SMA in the wound was determined using immunofluorescent assay (n = 4; ∗p < 0.05 and NS = no significance).