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. 2021 Sep 20;12:719562. doi: 10.3389/fimmu.2021.719562

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Copyright © 2021 Xu, Prens, Florencia, Leenen, Boon, Asmawidjaja, Mus and Lubberts

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-10 neutralization increases neutrophil and monocyte/DC infiltration in the IMQ-induced psoriasis mouse model. (A) Flow cytometry staining of Ly6G+Ly6Cint neutrophils among pregated CD45+CD11b+ cells in lesional psoriasis-like skin at day10. (B) Percentages and cell numbers of neutrophils among total CD45+ immune cells at day 10 in flow cytometry analysis and levels of the neutrophil chemokines, CXCL1 and CXCL2, in lesional psoriasis-like skin. (C) Representative IHC staining of Gr-1+ neutrophils in skin sections of the IMQ-induced psoriasis mouse model at days 5 and 10. (D) Flow cytometry staining of CD11c+Ly6Cint monocyte-derived dendritic cells in lesional psoriasis-like skin at day10. (E) Percentages and cell numbers of monocyte-derived dendritic cells (mono/DCs) among total CD45+ immune cells at day 10 using flow cytometry. Data are shown as means ± SEMs. *P < 0.05, **P < 0.01, and ***P < 0.001.