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. 2021 Sep 20;12:734282. doi: 10.3389/fimmu.2021.734282

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Copyright © 2021 Verstegen, Ubels, Westerhoff, van Ham and Barberis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Models of Germinal Center B cell (GCBC) recycling between the light zone (LZ) and the dark zone (DZ). (A) Centrocyte (CC) selection through binding strength of the BCR to an antigen provided by follicular dendritic cells (FDCs). CC then migrates to the DZ and becomes centroblast (CB). Black arrows indicate the GCBC migration. (B) Increase in the refraction rate between CCs and FCDs. (C) Verification step, where CCs are selected by Tfh cells after a first selection by FDCs. (D) Spontaneous oscillations of GCBC between CXCL12 (representing the LZ) and CXCL13 (representing the DZ).