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. 2021 Sep 20;8:728496. doi: 10.3389/fmed.2021.728496

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Copyright © 2021 Calcat-i-Cervera, Sanz-Nogués and O'Brien.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological properties of tissue-derived MSCs. MSCs can be isolated from adult tissue sources such as adipose (AT)- and bone marrow (BM), as well as perinatal and/or birth-associated tissues, including amniotic liquid (AM), cord blood (CB), placenta (P) or umbilical cord (UC) tissues. Tissue of origin have shown to impact the biological properties of MSCs. This figure illustrates the main differences described in the literature regarding growth kinetics, differentiation abilities, immunophenotype, secretome, and immune modulation between cell sources. Created in BioRender.com.