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. 2021 Sep 20;12:731845. doi: 10.3389/fimmu.2021.731845

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Copyright © 2021 Deacy, Gan and Derrick

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Binding of SpA, SpG and PpL to antibody Fab fragments: (A) Left panel: ribbon plot of SpA (Red) bound to V_H3 domain of IgM Fab (Green) (PDB code: 1DEE). Middle panel: IgM Fab showing polar (red) and hydrophobic residues (blue). Right panel: SpA. (B) Left panel: ribbon plot of SpG (Orange) bound to C_H1 domain of IgG Fab (Cyan) (PDB code: 1QKZ). Middle panel: IgG Fab. Right panel: SpG. (C) Left panel: ribbon plot of PpL Domain B₁ (Purple) interface 1 bound to IgM Fab (Green) at the V_L domain (PDB code: 1HEZ). Middle panel: IgM Fab. Left panel: PpL. (D) Left panel: ribbon plot of PpL Domain B₁ (Purple) interface 2 bound to IgM Fab (Blue) at the V_L domain (PDB code: 1HEZ). Middle panel: IgM Fab. Right panel: PpL.