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. 2021 Sep 20;12:731845. doi: 10.3389/fimmu.2021.731845

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Copyright © 2021 Deacy, Gan and Derrick

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Binding of SpA and SpG superantigens to -IgG Fc. (A) Left panel: ribbon plot of SpA Domain B (Orange) bound to IgG Fc (Pink) at the C_H2-C_H3 interface (PDB code: 5U4Y). Middle panel: IgG Fc showing polar (red) and hydrophobic residues (blue). Right panel: SpA. (B) Left panel: ribbon plot of SpG Domain C2 (Blue) bound to IgG Fc (Orange) at the C_H2-C_H3 interface (PDB code: 1FCC). Middle panel: IgG Fc. Right panel: SpG.