FIGURE 1.
Acetoacetate, formed primarily from β‐oxidation of fatty acids, can be reduced to β‐hydroxybutyrate (BOHB) or decarboxylated to acetone. Beta‐hydroxybutyrate dehydrogenase (BDH) interconverts acetoacetate and BOHB depending on intercellular conditions (e.g., NADH). Acetone is produced via spontaneous or catalytic decarboxylation of acetoacetate. NADH, nicotinamide adenine dinucleotide