Figure 1. Design and timeline of the randomized controlled trial to be implemented on Pemba Island (Tanzania).

The study is designed as a five-arm trial including two arms with combined treatment through co-administration of separate tablets (arm A; moxidectin/albendazole, arm B; ivermectin/albendazole) and three arms with single drug administration (arm C; albendazole, arm D; ivermectin, arm E; moxidectin).

Abbreviations: ALB, albendazole; MOX, moxidectin; IVM, ivermectin; PK, pharmacokinetics.