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. 2021 Oct 4;9(19):e15047. doi: 10.14814/phy2.15047

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© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Experimental setup. Participants were randomized to low‐ or high‐intensity exercise and performed 2 weeks of exercise training (stationary bike) at the assigned intensity. PPT (arrows) were assessed immediately before and immediately after the first and last exercise sessions of the 2‐week training period. After the initial 2 weeks of training, participants underwent a 6‐week no exercise washout period and then returned to complete the exercise intervention at the other intensity. HRR, heart rate reserve; PPT, Pressure Pain Threshold