Figure 1. Cryo‐EM structure of SERCA2b WT in the E1∙2Ca²⁺ state.

1. Catalytic cycle for SERCA to transport Ca²⁺ from the cytosol to the ER lumen through ATP hydrolysis. The intermediate state of which cryo‐EM structures have been determined in this work is colored magenta.
2. Cryo‐EM map of SERCA2b WT in the E1∙2Ca²⁺ state (upper) and its cartoon representation (lower). The A, N, and P domains and transmembrane helices (TM1−TM11) are colored yellow, magenta, cyan, and wheat, respectively.