Fig. 4.

Complex crystal structure of functional, truncated IbpA shows unconventional binding to mouse VH5 Fab clone 338E6 involving heavy and light chains. (A) Crystal structure showing two distinct interfaces between truncated IbpA and heavy and light chains of two mouse VH5 Fab fragments. Simplified cartoon present in lower right corner. (B) Close-up view of interface 1 between heavy chain (blue, surface representation) and participating residues of the HCBD (green-teal, cartoon representation); BSA ∼670 Å. (C) Close-up view of interface 2 between light chain (light blue, surface representation) and participating residues of Domain D (pink, cartoon representation); BSA ∼380 Å.