Table 1.

Inhibitory activities of selected compounds against purified 20S and against Pf and mammalian cancer cell lines

IC₅₀ values for the compound set against Pf20S and Hs20S β5c/β5i activity. For Pf20S β5-selective compounds, MPI-5 to 14, enzyme assay IC₅₀ values are the concentrations, resulting in 50% inhibition of the total inhibitable β5 activity. Data represent the mean ± SEM and n is the number of independent experiments. LD₅₀ for toxicity against cell lines after 72 h. Data represent the mean ± SEM for three independent experiments, each performed in triplicate (3D7), and greater than two independent experiments (HepG2). BTZ = bortezomib.

^*Data from ref. 11.