Table 1.

ExoBlock reverses exosome-mediated inhibition of different T-cell activation endpoints

Activation period	Activation endpoint	% inhibition with exosomes	% inhibition with exosomes+ExoBlock	% reversal of Inhibition by ExoBlock
2 hours	Nuclear translocation of NFκB	53	15	71
2 hours	CD69 upregulation	46	11	75
6 hours	Intracellular IL-2 expression	45	11	75
3 days	Intracellular IFN-γ expression	69	26	63
3 days	CD25 upregulation	77	13.5	82
7 days	Proliferation (Expansion Index)	67	15.5	77

IFN-γ, interferon gamma; IL, interleukin.