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. 2021 Oct 1;9(10):e003001. doi: 10.1136/jitc-2021-003001

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Evolutionary analysis reveals clade-specific neoantigens in colorectal adenocarcinoma (CRC)2 and renal cell carcinoma (RCC) cases. (A) Somatic mutation calls were used to create sorted binarized mutation heatmaps for each case. (B) The mutation data were also used to reconstruct mutational phylogenies of each tumor. The early branching evolutionary pattern in RCC and CRC2 cases contrasts with a more truncal pattern in the non-small cell lung carcinoma (NSCLC) and urothelial bladder carcinoma (UBC) cases. For the RCC and CRC2 cases, the green and blue arrows in (A) and circles in (B) indicate clade-specific mutations shared across multiple tumor regions. C, chest wall met; GL, germline; IV, tumor thrombus; LN, lymph node; LV, liver met; OM, omental met; P, primary; SN, satellite nodule; U, uretal mass.