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. 2021 Oct 1;9(10):e003001. doi: 10.1136/jitc-2021-003001

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Distributions of global coding mutations across indications. The absolute numbers of global mutations per tumor were determined from published multiregion sequencing studies (limited to cases with at least three tumor regions). Mutation data were collected from Hu Nat Gen 2019, Jamal-Hanjani NEJM 2017, Gerlinger Nat Gen 2014, Lamy Cancer Res 2016, Faltas Nat Gen 2016, Heide J Pathol 2019. The five cases from the present study are indicated by red triangles. Note that all published non-small cell lung carcinoma (NSCLC) cases were non-metastatic and there was some intervening treatment in the urothelial bladder carcinoma (UBC) studies. *The median global neoantigens per indication for previously published cases was estimated from the global neoantigen numbers in the current study using a linear model (see ‘Methods’ section and online supplemental table 2). CRC, colorectal adenocarcinoma; RCC, renal cell carcinoma.