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Predicted top upstream regulators. (A) Hierarchical elucidation of the significantly affected potential upstream regulators observed to experimentally affect the differentially expressed CSF protein clusters at 4h and 1w. The significance threshold [-log (p-value) >1.3] was determined by IPA analysis. Proteins associated with the respective predicted upstream regulators and their expression profiles at 4 h and 1 w are as follows: (B) TNF, (C) mTOR, (D) IGF1, (E) BDNF and (F) IL6.
