Fig. 6.

Mechanistic network analysis of the predicted upstream regulators. (A) Hierarchical clustering of the significantly affected potential upstream regulators observed to experimentally affect the differentially expressed CSF protein clusters at 4h and 1w. The activation z-score of the regulators is depicted as orange (activated) and blue (inhibited), which was determined by IPA analysis. Elucidation of the interaction networks of the mechanistic activation/inhibition of the top significantly predicted upstream regulators and the associated regulated proteins at (B) 4h and (C) 1w.