Table 4.
Patient‐reported severity of dexamethasone‐related side effects
| Side effect | NEPA + DEX1 n (%) | NEPA + DEX3 n (%) | NEPA + DEX4 n (%) |
|---|---|---|---|
| Indigestion/heartburn or reflux | (n = 74) | (n = 74) | (n = 74) |
| Not at all | 36 (48.6) | 33 (44.6) | 38 (51.4) |
| A little bit | 17 (23.0) | 16 (21.6) | 17 (23.0) |
| Quite a bit | 10 (13.5) | 16 (21.6) | 14 (18.9) |
| Very much | 11 (14.9) | 9 (12.2) | 5 (6.8) |
| Insomnia | (n = 75) | (n = 74) | (n = 75) |
| Not at all | 43 (57.3) | 38 (51.4) | 35 (46.7) |
| A little bit | 19 (25.3) | 17 (23.0) | 21 (28.0) |
| Quite a bit | 8 (10.7) | 13 (17.6) | 16 (21.3) |
| Very much | 5 (6.7) | 6 (8.1) | 3 (4.0) |
| Hiccups | (n = 75) | (n = 74) | (n = 75) |
| Not at all | 52 (69.3) | 46 (62.2) | 43 (57.3) |
| A little bit | 12 (16.0) | 22 (29.7) | 16 (21.3) |
| Quite a bit | 9 (12.0) | 4 (5.4) | 10 (13.3) |
| Very much | 2 (2.7) | 2 (2.7) | 6 (8.1) |
| Agitation | (n = 75) | (n = 74) | (n = 75) |
| Not at all | 40 (53.3) | 37 (50.0) | 34 (45.3) |
| A little bit | 21 (28.0) | 14 (18.9) | 26 (34.7) |
| Quite a bit | 11 (14.7) | 19 (25.7) | 14 (18.7) |
| Very much | 3 (4.0) | 4 (5.4) | 1 (1.3) |
| Facial rash/ acne | (n = 75) | (n = 74) | (n = 75) |
| Not at all | 70 (93.3) | 61 (82.4) | 69 (92.1) |
| A little bit | 5 (6.7) | 8 (10.8) | 4 (5.3) |
| Quite a bit | 0 | 4 (5.4) | 1 (1.3) |
| Very much | 0 | 1 (1.4) | 1 (1.3) |
Abbreviations: DEX1, dexamethasone day 1; DEX3, dexamethasone day 1 to 3; DEX4, dexamethasone day 1 to 4; NEPA, fixed‐dose combination of netupitant and palonosetron.