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. 2021 Aug 4;26(10):854–864. doi: 10.1002/onco.13901

Figure 3.

Figure 3

Changes in tumor density and intratumoral blood flow before (left panel) and after (right panel) dovitinib treatment. After 3 days of dovitinib treatment, one poorly differentiated patient with hepatocellular carcinoma demonstrated (A) massive necrosis on computed tomography (CT) scan and (B) 63% decrease in tumor arterial flow on perfusion CT. Even though 14% increase in tumor size was visible on CT scan, the lesion had become largely necrotic and ruptured. (C): At emergency hemihepatectomy, large fields of necrosis were macroscopically visible.