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. 2021 Sep 21;77(Pt 10):328–333. doi: 10.1107/S2053230X21008943

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© Sarah K. Alvarado et al. 2021

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

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(a) DynU16 (PDB entry 6v04) adopts a helix-grip fold with a di-domain architecture. (b) The surface view shows the cavity formed between the N-terminal domain (left) and the C-terminal domain (right). (c) The elongated cavity is composed of aromatic residues localized towards the N-terminal domain and polar residues towards the C-terminal domain. The aromatic residues are positioned to stabilize the hydrophobic polyene substrate. The side chains lining the cavity are shown as sticks in cartoon representation, with C atoms shown in sky blue, N atoms in dark blue and O atoms in red. The surface of the cavity is shown to illustrate its size between the domains and the two openings. The figure was generated with PyMOL (version 2.4.1; Schrödinger).