TABLE 4.
Sensitivity analysis of the FA + Sm + D model1 using highly correlated FAs
| FA2 (HR from FA + Sm + D model) | Highly correlated3 FA (correlation) | Average HR ± SE with highly correlated FA4 | Average concordance ± SE using highly correlated FA4 |
|---|---|---|---|
| 16:1n–7 (1.25) | 16:0 (0.62) | 1.12 ± 0.06 | 0.786 ± 0.01 |
| 22:0 (0.93) | 24:0 (0.80) | 0.91 ± 0.03 | 0.787 ± 0.01 |
| 24:1n–9 (0.73) | 0.90 ± 0.03 | 0.789 ± 0.01 | |
| O3I (0.85) | 22:4n–6 (–0.59) | 1.09 ± 0.06 | 0.789 ± 0.01 |
| 22:5n–6 (–0.52) | 1.12 ± 0.04 | 0.791 ± 0.01 |
1
The FA + Sm + D model consists of age, sex, 4 FA metrics [14:0, 16:1n–7, 22:0, and O3I (20:5n–3 + 22:6n–3)], current smoking status, and prevalent diabetes. The model (Figure 1) has a concordance ± SE = 0.790 ± 0.01 and n = 2240. A, age; D, diabetes; FA, fatty acid; O3I, omega-3 index; S, sex; Sm, smoking.
2
14:0 had no highly correlated FAs except 16:1n–7, which was already in the model.
3
Correlation of ≥0.5 from Supplemental Table 2 (except for 20:5n–3 and 22:6n–3 because these 2 FAs constitute the O3I).
4
Across the 10 validation models.