TABLE 2.

Subunits of yeast TFIIIC

Subunit	Calculated mass (kDa)	Gene	Null phenotype	Location and proposed role in TFIIIC-DNA complex	Features	Source(s) or reference
τ138	132	TFC3	Lethal	In τB; B block binding	Two HMG domains
τ131	120	TFC4	Lethal	Most 5′; TFIIIB assembly; interacts with TFIIIB70 and TFIIIB90	11 TPR motifs; phosphorylated; ortholog in H. sapiens, C. elegans, and K. lactis	23, 41a
τ95	74	TFC1	Lethal	In τA; A block binding; interacts with τ55	Ortholog in H. sapiens, D.m., C. elegans and S. pombe	23, 27a
τ91	75	TFC6	Lethal	Most 3′; cooperates with τ138 in DNA binding	(Cys+His)-rich domain; ortholog in H. sapiens and S. pombe	1a
τ60	68	TFC8	Lethal	In τB; TFIIIB assembly; interacts with TBP
τ55	49	TFC7	Lethal	In τA; interacts with τ95	Chimeric protein