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. Author manuscript; available in PMC: 2021 Oct 4.
Published in final edited form as: Methods Mol Biol. 2021;2293:273–294. doi: 10.1007/978-1-0716-1346-7_20

Fig.3. Early endosomes in DS.

Fig.3

a, Representative immunofluorescence micrographs of rab5-positive endosomes in DS and age-matched 2N controls. DS fibroblast show a striking enlargement in the size of rab5-positive endosomes compared to 2N. b, The numbers of EEA1-positive early endosomes in all size groups are also increased in the DS fibroblasts compared to 2N controls (total fibroblasts examined: 2N fibroblasts = 80; DS fibroblasts = 80).