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. 2021 Oct 4;22:282. doi: 10.1186/s13059-021-02493-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Motif enrichment analysis reveals alx transcription factor family as putative regulator of iridophore development. a, b Heatmaps representing motif enrichment, gene expression, and gene fold change of transcription factors when comparing late NCC differentiation into melanophores (a) and iridophores (b). c Bar plots representing frequency and distribution of iridophore-associated DM/ARs with a particular TF motif. d Heatmaps representing DNA methylation and ATAC signal across iridophore-associated DM/ARs with specific TF motifs. e ATAC-seq footprint signatures of alx transcription factor candidates. f Model of guanine synthesis cycle. Iridophore-specific DEGs are shown in bold. Boxes above DEGs are color-coded based on detection of CREs containing TF motifs within 50 kb of DEG promoters