FIGURE 1.

Experimental outline of animals used in these studies. (a) 71 mice at 4–6 weeks of age were used to generate hippocampal and liver extracts for immunoblotting, RNA, proteasomes, and brain sections for immunohistochemistry. (b) 37 timed pregnant mice were used for the production of cortical neuronal cultures for immunoblotting and neuronal viability assays. A total of 108 postnatal mice were used for the experiments described in this study